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It is also a chemical precursor to glutathione, a powerful antioxidant which protects cells from free radical damage

Future medicinal chemistry efforts may yield next-generation compounds with enhanced properties, including improved tissue selectivity, modified pharmacokinetics, or additional mechanistic activities that complement NNMT inhibition

However, few therapies are cell death signaling-targeted even though the various cell death modes are present throughout the progression of NAFLD/NASH