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(2017) Mechano growth factor, a splice variant of IGF-1, promotes neurogenesis in the aging mouse brain
www.elsevier.com/locate/toxicol
Importantly, converging clinical and preclinical data support a bidirectional interplay whereby circadian disruption and sleep disorders not only emerge early in the disease course, but also aggravate neurodegenerative processes and deeply affect the quality of life of patients and caregivers, underscoring the potential of circadian-based interventions as disease-modifying strategies [13]
doi: 10.1038/nature09267 [DOI] [PMC free article] [PubMed] [Google Scholar] 87
