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The induction of CIPN by axonal degeneration is thought to be due to a loss of nicotinamide adenine dinucleotide (NAD +) via the SARM1 pathway [73]
UCP1 gene expression was already significantly decreased to around 50% after 2 h of 4CBA treatment, showing a rapid response to CoQ deficiency, with a peak decrease in expression after 48 h where expression was less than 10% of control cells (Fig
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