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For example, as one of the significantly expressed miRNAs, miR-30e-5p was involved in the prevention of tumor growth and angiogenesis in gallbladder cancer via the PI3K/Akt pathway (Jin et al., 2018), while the inhibition of miR-30a-5p significantly promoted proliferation, migration, invasion, epithelial-interstitial transformation, and apoptosis of NON-small cell lung cancer cells, and enhanced the PI3K/Akt expression (Wang et al., 2020