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The pooled relative risk for otoprotection at 4 to 6 weeks was 0.14 (95% CI: 0.05 to 0.45), and the risk difference was -33% (95% CI: 46% to 21%)
Patients who continue into a second cycle generally report more sustained and visible results because the cumulative signaling effect compounds over time

Increased oversight by the FDA, FTC, or state agencies can help to ensure that the benefits of compounded GLP-1 products for weight loss outweigh the risk

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