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3-AB can have off-target effects and less potency, making it mainly a research tool rather than a therapeutic agent 177
Treatment of paroxysmal disorders such as epilepsy required timely drug release

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In diabetic nephropathy, podocyte NOX4derived HO drives podocyte injury and slit-diaphragm defects, thereby promoting albuminuria [345], whereas in diabetic retinopathy PKC-driven and VEGF-driven permeability changes are tightly linked to oxidative stress [346]