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[8] A 2010 review had concluded that nicotinic acid was effective as a mono-therapy, [9] but a 2017 review incorporating twice as many trials concluded that prescription nicotinic acid, while affecting lipid levels, did not reduce all-cause mortality, cardiovascular mortality, myocardial infarctions, nor fatal or non-fatal strokes

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First isolated in 1977 from rabbit cerebral venous blood, DSIP is classified as amphiphilic, meaning it contains both water-attracting and water-repelling regions