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Description
Areas of uncertainty in toxicity values generally include extrapolation from controlled high-dose animal studies to the human general population (including potentially sensitive subgroups) and generally lower exposure levels, determining if rodent endpoints are relevant to humans (e.g., tumors in the Zymbals gland of rodents), route-to-route extrapolation if toxicity values are lacking for certain exposure pathways, extrapolation from shorter-duration exposure studies to chronic or lifetime risk, and data gaps in the underlying toxicity database

Glutathione accumulation in detached leaves exposed to H2S in the absence of light is stimulated by the supply of glycine to the petiole

A recent study showed that nearly 1 in 6 patients with cirrhosis have moderately severe to severe depression and nearly half have moderatesevere anxiety (43)
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