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Furthermore, decreased bacterial richness has been linked to high carbohydrate 73 and high-fat/low-protein concentrations 74 , as found in the lean and Western diets, respectively, the latter result only in old-aged rats 74

LL-37: Antimicrobial Defense and Mucosal Immunity Mechanism of Action: LL-37 is a cathelicidin antimicrobial peptide that supports innate immunity and protects the gut lining from microbial invasion

In the SURMOUNT-1 trial with 2,539 adults with obesity, participants on the highest tirzepatide dose (15 mg weekly) lost an average of 20.9% of their body weight over 72 weeks