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PMID 15294905
10.3390/ijms24021436 Int
Many candidate compounds (such as curcumin) have poor oral bioavailability, rapid metabolism, formulation-dependent exposure, and uncertain CNS penetration, while plasma pharmacokinetics may not accurately represent drug levels within compartmentalized CNS lesions, especially in progressive disease (Liu et al., 2016
1 2 "Levothyroxine Drug Usage Statistics, United States, 2014 - 2023"
