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Subsequently, the CRGDR/K peptide containing the C-terminal CendR motif (R/KXXR/K) binds to neuropilin-1, activating an endocytic pathway 13,14,15

This in turn enables the activation of defense signaling proteins and transcription factors which helps to establish innate immune memory (Lindermayr and Yildirim, 2025)

In conditions such as OSAHS, CIH typically leads to a suppression of the stress reflex, indicating that estrogen may also ameliorate SNA in OSAHS through this pathway

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