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Boxer's, Doberman pinschers, Cavalier King Charles Spaniels, etc.) are advised to have echocardiograms performed prior to Adriamycin administration even if there is no obvious evidence of heart disease present (abnormal heart rhythm, murmur, radiographic heart enlargement, etc.)

L-2-Hydroxyglutaric aciduria (L-2-HGA) is caused by mutations in the gene encoding L-2-hydroxyglutarate dehydrogenase (LHGDH), leading to the accumulation of L-2-HG in the brain and biological fluids, which is the biochemical hallmark of L-2-HGA [111, 112]

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