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One honest caveat up front, because it shapes everything below: the evidence base for 5-Amino-1MQ is almost entirely preclinical mouse and cell-culture studies
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The three lead compounds, 78c (IC50 7.3 nM), 1ai (IC50 46nM), and Iah (IC50 115nM), increased NAD levels in muscle and liver of diet-induced obese mice [78-79]
