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Circulatory shock with fever, severe hypotension, and confusion requiring intravenous fluid resuscitation and vasopressors has occurred within minutes to hours of re-challenge with sulfamethoxazole and trimethoprim products, including sulfamethoxazole and trimethoprim injection, in patients with history of recent (days to weeks) exposure to sulfamethoxazole and trimethoprim
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10.1016/J.CELL.2010.01.040 40 SlavichG

391 However, more research and direct evidence are needed for MG intervention
