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Description
Identification of the NRF2 transcriptional network as a therapeutic target for trigeminal neuropathic pain
For example, lactate can activate the HIF-1 pathway in microglia to enhance pro-inflammatory cytokine release, while IL-1 can inhibit neuronal PGC-1 expression to impair mitochondrial biogenesis, forming a potential link between peripheral immune metabolic reprogramming and central neuroinflammation and energy deficiency
Acta Radiol 51:11261136
10.1016/s0021-9258(18)64190-0 49 EagleH
