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The Panel used the IC/BPS definition agreed upon by the Society for Urodynamics and Female Urology (SUFU): "An unpleasant sensation (pain, pressure, discomfort) perceived to be related to the urinary bladder, associated with lower urinary tract symptoms of more than six weeks duration, in the absence of infection or other identifiable causes. 2 This definition was selected because it allows treatment to begin after a relatively short symptomatic period, preventing treatment withholding that could occur with definitions that require longer symptom durations (i.e., six months)

Thus, the events in the rats after removal of the bilateral carotid artery ligation may be the followup of the observed activation of particular pathways with local and systemic relevance in the rats with ligation of the inferior caval vein receiving BPC 157 therapy (Vukojevic et al., 2018)