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A proportional shift from glucose dependence to FAAO utilization and simultaneous upregulation of several metabolic pathways underly immune-suppressive phenotypes tol-DC We next applied single-cell approaches to investigate DC skewed to be tolerogenic to identify critical metabolic features and potential biomarkers defining the major modes of in vitro tolerogenic DC generation
Asparagine Biosynthesis Asparagine is synthesized from aspartate via an amidotransferase reaction catalyzed by asparagine synthetase
J Cell Physiol 233(10):65306537
