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In contrast to the outcomes observed with NINJ1 knockdown, NINJ1 overexpression significantly enhanced ferroptosis induced by erastin (Fig

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Given the substantially larger size of the E3 ubiquitin-ligase family (over 600 members) compared to the more manageable number of USPs (~50 members), we focused on USPs to explore their involvement in regulating TGFBR1 in Sirt2 knockout (S2KO) cells