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Therefore, cancer cells not only use FAO to oxidize fatty acids and to derive energy by mitochondria but they also use acetyl-CoA to endogenously synthesize fatty acids in the cytosol using NADPH as key cofactor for anabolic enzymes (Koundouros and Poulogiannis, 2020)
Fatty Acid Activation and Transportation to the Mitochondria For oxidation, fatty acids with carbon chains more than 14 carbons need activation before passing through the mitochondrial membrane
The result is a leakage of ROS from the mitochondria [38]
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