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Keywords: oxidative damage, oxidative stress, reactive oxygen species, redox signaling, therapeutic targets Oxidative stress occurs when the reactive oxygen species (ROS) production overwhelms the ROS scavenging, which lead to genomic instability, epigenetic regulation, proteostasis imbalance, and lipid peroxidation, subsequently causing the occurrence and development of numerous diseases

11 By comparison, GSTP1 can arrest tumor cells in the G0/G1 phase and upregulate the expression of p21 in bladder cancer

They are water-soluble and function in the cytoplasm and mitochondria [47,76-79]