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Spielmann, A

105 mTOR is a serine/threonine kinase that serves as the catalytic subunit of the mTORC1 protein complex, which phosphorylates its two major effector proteins S6 kinase beta-1 (S6K1) and eukaryotic initiation factor 4E-binding protein 1 (4EBP1), both of which facilitate eIF4F-mediated translation

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Moreover, the circadian rhythm of peripheral tissue is responsive to the feedingfasting cycle [235].Timerestricted circadian feeding, which involves setting the feeding period to a defined interval without a reduction in caloric intake, is associated with systemic inflammation [236, 237]