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In addition to IGF pathways, anti-tumor effects on PI3K/AKT/mTOR and MAPK/ERK pathways with metformin exposure were observed, leading to the upregulation of markers of cell cycle arrest, apoptosis, and autophagy and downregulation of markers associated with senescence and the inhibition of cell migration (Hanna et al., 2012

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Complete oxidation of the two moles of pyruvate, through the actions of the pyruvate dehydrogenase complex (PDHc) and the reactions of TCA cycle, yields an additional 30 moles of ATP

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