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The early progenitors within the adult SGZ and SVZ retain the capacity to specify multiple cell types and it is clear that TF networks determine fate specification and differentiation of newly born neurons

Thus, as is seen with leptin, glucocorticoids contribute to a reduced ability of insulin to inhibit NPY/AGRP neurons in the ARC, which has the converse effect of lessening appetite suppression ( Glucocorticoids also influence food intake by enhancing the preference for comfort foods. Insulins suppressive effect on reward pathways likely means the food needs to be more rewarding to achieve the same effect

Israel BA, Sherman FS, Guthrie RD

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