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2023 Aug 1 [cited 2025 Jul 22];13(8):327799

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[78] [79] The reaction of transition metals with proteins oxidated by reactive oxygen or nitrogen species can yield reactive products that accumulate and contribute to aging and disease

Thus, high bilirubin concentrations (100 M) resulted in early necrosis, but low-to-moderate doses (0.6625 M) primarily resulted in delayed apoptosis [22]