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Description
Glutamine is absorbed in the upper part of the small intestine and subsequently metabolised in the liver, thus it may not be available in sufficient quantity for other tissue targets, such as immune and muscle cells, to have a measurable effect

This resulted in the identification of four prominent clusters

Since mitochondrial metabolism is prevalent in normal high-energy-demand tissues, such as the heart and liver, OXPHOS inhibitors (e.g., IACS-010759) have shown dose-limiting toxicities (DLT) in some clinical trials, hindering their widespread application [173]

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