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GPx1-deficient endothelial cells were more susceptible to the effects of inflammatory mediators, such as TNF (tumor necrosis factor ) and lipopolysaccharide, than cells with normal levels of GPx1

Biochem Pharmacol 176:113886
28 IbrahimH.PerlA.SmithD.LewisT.KonZ.GoldenbergR.et al

Dysregulation of tryptophan catabolism at the host-skin microbiota interface in hidradenitis suppurativa