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PKM2 is implicated in microglial polarization, with high expression correlating with increased metabolic activity and energy demand, driving microglial activation and metabolic shifts [25]
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Moreover, increased cellular uptake of Zn 2+ through the upregulation of zinc transporter ZIP8 activates metal-regulatory transcription factor-1 (MTF1), which in turn induces the expression of matrix-degrading enzymes in chondrocytes 33,83
Begaye B, Vinales KL, Hollstein T, Ando T, Walter M, Bogardus C, Krakoff J, Piaggi P
