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Sheyn, D

The study demonstrated elevated pain thresholds following DSIP administration in the hot plate test, particularly during the dark phase, and the effect was not blocked by naloxone, indicating a non-opioid analgesic mechanism

doi: 10.1186/s13075-023-03181-w [DOI] [PMC free article] [PubMed] [Google Scholar] 256.Lucas V, Cavadas C, Aveleira CA

This signaling in the brain can be either excitatory or inhibitory
