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Pajouhesh, H

Abbreviations AC: Aconitine ADME: Absorption, distribution, metabolism, excretion ADMET: Absorption, distribution, metabolism, excretion, and toxicity AFB1: Aflatoxin B1 AFB2: Aflatoxin B2 AFG1: Aflatoxin G1 AFG2: Aflatoxin G2 AFM1: Aflatoxin M1 AI: Artificial intelligence ALI: Acute lung injury ASDs: Amorphous solid dispersions AUC: Area under the concentrationtime curve BBB: Bloodbrain barrier BBR-NE: Berberine into nanoemulsion BCS: Biopharmaceutics classification system BCSCC: Biopharmaceutics classification system of Chinese materia medica composition BLNM: Baicalin nanomicelles BZYXP: Baiziyangxin pills BYD: Baoyuan deocction CA-VO: Chuanxiong Rhizoma And Angelicae Sinensis Radix volatile oils ChP: Chinese Pharmacopoeia CIT: Citrinin CL: Clearance C max : Maximum plasma concentration CNS: Central nervous system CSAN: Chinese medicine self-assembly nanostrategy CTD: Cantharidin CYP450: Cytochrome P450 DL: Deep learning DON: Deoxynivalenol FB1: Fumonisin B1 FB3: Fumonisin B3 GCMS: Gas Chromatography-Mass Spectrometry GLUT: Glucose transporter GST: Glutathione-S-transferases GPCR: G protein receptors HA: Hypaconitine HHI: Herb-herb interactions HDI: Herb-drug interactions HRMS: High-resolution mass spectrometry HSA: Human serum albumin ICD: Immunogenic cell death LBP: Lycium barbarum polysacharides LCMS: Liquid chromatography LCMS/MS: Liquid chromatography-tandem mass spectrometry LMB: LipoMicel Berberine MA: Mesaconitine ML: Machine learning MRP: Multidrug resistance-associated transporter NDDS: Nano drug delivery systems OAT: Organic anion transporter OCT: Organic cation transporter PAs: Pyrrolizidine alkaloids PAT: Patulin Papp: Apparent permeability coefficient PD: Pharmacodynamic PEPT: Peptide transporter PEG: Polyethylene glycol P-gp: P-glycoprotein PK: Pharmacokinetic PLGA: Polylactic acid-glycolate PRTS: Raridis Phizoma Total saponins QbD: Quality by design Q-marker: Quality Marker QSAR/QSPR: Quantitative structureactivity relationship/quantitative structureproperty relationship QuEChERS: Quick, easy, cheap, effective, rugged, and safe QZJFD: Qingzaojiufei decoction RF: Random forest SPE: Solid-phase extraction SO 2 : Sulfur dioxide SULT: Sulfotransferases SAB: Salvianolic acid B TA: Total alkaloids TCM: Traditional Chinese medicines T max : Shortens the time to peak T 1/2 : Prolongs the half-life TDC: Tyrosine decarboxylase UGT: UDP-glucuronosyltransferases XST: Xuesaitong injection YZP: Yuanhuzhitong plate YZDP: Yuanhuzhitong dropping pills ZEN: Zearalenone References Chen SY, Zeng JS, Li R, Zhang YR, Tao YW, Hou Y, et al

Perspective of leptin therapy: leptin and cognitive function Recent studies have demonstrated that obesity is associated with an increased risk of depression (Roberts et al., ob genes (Matochik et al., Taking together, leptin replacement therapy could be therapeutic opportunities not only for obesity and diabetes, but also for obesity-related depression and anxiety (Johnston et al., Conclusion The control of food intake, energy expenditure, and glucose metabolism is controlled by a complex regulatory network that depends on central and peripheral crosstalk, such as found in brain-adipo signaling