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In conclusion, these findings demonstrate that a clinical intervention for 3-months with oral L-GSH in individuals with T2DM can decrease levels oxidized GSH, while maintaining levels of reduced GSH and overall reducing the extent of oxidative stress

Specifically, it can significantly enhance the sensitivity of melanoma cells to IR by regulating the mitochondrial-dependent apoptotic pathway, thereby exerting a radiosensitizing effect

Based on the REDEFINE 1 trial protocol, the standard dosing schedule progresses over 20 weeks to reach maximum maintenance levels [3]

10.1056/NEJMoa1401739 N Engl J Med
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