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Despite the clear connection between UPR mt activation and longevity in the context of mitochondrial translation inhibition, UPR mt activation is also observed in short-lived mitochondrial mutants, and constitutively active alleles of ATFS-1 exhibit reduced lifespan 15

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The normality of metabolite distributions was assessed using the Shapiro-Wilk test

CRISPR interference interrogation of COPD GWAS genes reveals the functional significance of desmoplakin in iPSC-derived alveolar epithelial cells
