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In a placebo-controlled, phase 2 trial, the authors found that the intravenous administration of dazodalibep led to a significant reduction in the DAS28-CRP score by day 113, while no major safety concerns were raised (31)
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At the end of the treatment the media were removed and replaced with 1 mg/ml MTT (prepared in the same medium) and incubated for 2 h
It was found that these key enzyme-encoding contained a great quantity of light-response elements and hormone-response elements through promoter analysis
