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A 2.0 2.0 2.0 cm (8 cm 3 ) 1 H-MRS voxel was placed in the bilateral dorsal ACC (see Fig

Proline DCs are classic innate immune cells, and studies have shown that proline modulates innate immunity in Caenorhabditis elegans by balancing redox homeostasis and activating the key transcription factor SKN-1 associated with pathogen defense (115)

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In vitro, astrocytes derived from induced pluripotent stem cells obtained from patients with FTD-MAPT showed hypertrophy, elevated GFAP protein levels, disease-associated changes in TAU expression, increased vulnerability to oxidative stress, and protein ubiquitination 231