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Conclusion By focusing on the ROS-related PIPN mechanism, both antioxidant drugs (e.g., small molecular drugs, traditional medicines/active ingredients) and tailor-made nanosystems (e.g., tumor-targeting Pt nanosystems and anti-ROS nanosystems) have demonstrated to be effective in the prevention and treatment of PIPN

These findings led to preclinical studies that demonstrated that simultaneous targeting of tumor vessels and immunity is a viable strategy to normalize aberrant vascular-immune crosstalk and potentiate cancer immunotherapy

Most peptide reconstitution research workflows use bacteriostatic water for this reason