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[DOI] [PubMed] [Google Scholar] 106.Hamad G.G., Helsel J.C., Kozak G.M., McShea M.C., Hughes C., Confer A.L., McCloskey C.A., Sit D.K., Perel J.M., Wisner K.L.P.U.o.P.P.P.A.U.S

Int J Med Sci

Animals that were dosed with NPs developed mild to reduced pain

In the Billon 2023 paper, mice given 30 mg/kg IP still showed measurable plasma and muscle concentrations at 6 hours post-injection, which helps explain why twice-daily dosing was used in efficacy studies
