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In the study by da Silva Guimares et al ., [] the number of patients who discontinued at the end of the study was high due to death, sepsis, renal and liver diseases, shock, or loss during follow-up

The CDKAL1 genetic variants could predict the development of diabetes in individuals with impaired insulin secretion, which indicates that there may be potential synergistic and interactive effects among different risk factors [13, 41]

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