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Author contributions CF: Investigation, Data curation, Methodology, Writing review & editing, Conceptualization, Validation, Formal Analysis, Writing original draft

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The simulated results of molecular docking indicated that GHK-Cu can directly bind to SIRT1 to form a protein complex, and the interacting residues in the complex are composed of GLU-230 and ASN-226 (Figure 5E)

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Notably, injection site discomfort with GHK-Cu tends to be more frequent than with other peptides, due to the copper component

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