glutathione hydroxyl radical – Interaction: A Theoretical Study on Radical Recognition Process Intramolecular Hydrogen Transfer Reactions of

115, Feb

Combinations of these factors contributing to low GPx1 activity/levels will result in lower capacity to respond to reactive oxygen species (ROS), favouring accumulation of oxidative damage and promoting tumour progression

Since PV3-SC8 has previously been shown to bind pocket factors such as GPP3 in the VP1 hydrophobic pocket 18 , we investigated in situ if GSH binding interferes with this stabilisation mechanism by incubating a molar excess of GPP3 (VLP:compound molar ratio of 1:300) followed by GSH at 10 mM to form a ternary complex (PV3-SC8 GPP3+GSH ) with the PV3-SC8 VLP expressed in yeast 16

J., Bill, E., Essigke, T., Ullmann, G