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In addition, slow nocturnal body cooling also induced a significant phase advance of the N3 and REM patterns within the sleep cycle
Its substrate site-targeting mechanism inhibiting NNMT at the nicotinamide binding site provides selectivity over related methyltransferases and other enzymes in the NAD salvage pathway, making it a precise tool compound for studying NNMT-specific enzymatic activity in controlled laboratory systems
doi: 10.1038/s41531-022-00314-x
