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Elevated glutamine metabolism makes cancer cells more susceptible to glutamine deficiency caused by glutaminase inhibitors, which rapidly induces cell death [122]

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Among the HIF family, HIF-1 (rather than HIF-2 and HIF-3) plays an important role in metabolic regulation, as plentiful downstream genes of HIF-1 are highly related to the glucose metabolism process, such as GLUT1 , whose transcription and translation products participate in the intake of glucoses [2123]
