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Abstract Bipolar disorders (BD) represent a severe leading disabling mental condition worldwide characterized by episodic and often progressive mood fluctuations with manic and depressive stages

This hormonal preservation is especially relevant for individuals with existing endocrine considerations, those prone to stress-related eating, or anyone seeking to avoid the systemic hormonal disruptions that often accompany aggressive fat loss interventions

The buffer-exchanged PGRMC1 wild-type (apo and haem) and PGMRC1 C129S mutants were immediately analysed by nanoflow electrospray ionization MS using gold-coated glass capillaries made in house

Acknowledgments All the figures are drawn by FigDraw (www.figdraw.com)