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In its advanced stages, the bones begin to rub against one another, causing pain, stiffness and reduced mobility
Furthermore, a meta-analysis of multiple studies confirmed that ALA, when combined with other therapies, such as epalrestat, exhibited superior efficacy in improving nerve conduction velocities and reducing neuropathic pain (Zhao et al., 2018)
Proc Natl Acad Sci U S A 2010;107:8788-93
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