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[DOI] [PMC free article] [PubMed] [Google Scholar] 143.Klotz L

Rather than slowing gastric emptying or mimicking incretin hormones, tesofensine directly modulates central nervous system neurochemistry to influence appetite, satiety signaling, and energy expenditure

Notably, FDX1 plays a critical role in cuproptosis: when excess copper ions (particularly in the presence of copper ionophores) enter mitochondria, FDX1 reduces Cu 2+ to the more reactive Cu +

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