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This drug is a strong depressant that can produce dangerous and even fatal overdose symptoms

The average annual decline was 18 pmol/L for patients who had higher initial B12 levels, but for patients with lower initial B12 levels, the average annual serum decline was much higher at 28 pmol/L

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94 Although extremely promising, conversion of striatal astrocytes would not reproduce the nigrostriatal circuit, and conversion of nigral astrocytes would require coupling with an axonal pathfinding strategy as described above to elicit target connections to the striatum