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Together, CCPCA NPs could provide sufficient O 2 and PpIX for 5-ALA-PDT and consume GSH through Cu 2+ to increase the lethality of 1 O 2

Saudubray J-M, Garcia-Cazorla A

Keap1 facilitates redox-sensitive regulation of kinase activation by serving as a scaffold for upstream MAPK regulators, including PGAM5, and Ikk Keap1s function as a substrate adapter for cullin-3 E3 ligase enables it to target MAPK pathway components for ubiquitination and destruction, whereas oxidative alteration of its cysteine residue can change these proteinprotein interactions [91]