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Tarrag MG, Chini CCS, Kanamori KS, et al

Compared to larger macrocycles, the cavity size and donor atom arrangement of NOTA better match the coordination requirements of Cu(II) [67], making it one of the most efficient chelators of its generation for integrating into copper-based radiopharmaceuticals

Consider supplementation in asymptomatic patients with risk factors (see Table 2: Patient Risk Factors Associated with Folate Deficiency below) consider supplementation

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