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rhamnosus DNA activates TLR9 on intestinal epithelial cells, triggering the IRF3/STAT1 pathway to upregulate PD-L1 expression, which induces apoptosis in hyperactive Th2 cells via PD-1 binding (128)

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Also after Cd exposure in liquid culture PC levels were induced in a time and concentration dependent manner, whereas a less pronounced stimulation was found after Cu exposure [39,40]