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In addition, vascular DHFR protein content was decreased in db/db mice compared with db/m mice [40]

It also suggests the presence of additional factors that may modulate hepatocyte susceptibility to ferroptosis in parallel with GPx4

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Glutamine is involved in several biological functions, such as nucleotide synthesis, cell proliferation, regulation of protein synthesis and degradation, energy production, glycogenesis, ammonia detox, maintenance of the acid-base balance, among others