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Peer-reviewed literature indexed on PubMed Reviews GHK-Cu modulation of gene expression related to tissue remodeling and anti-inflammatory pathways

Inhibition of CYP51A1 with ketoconazole has demonstrated diverse biological effects: it rescued EGFR degradation in A431 carcinoma cells by blocking sterol metabolism upstream of MSMO1, and reduced inflammatory signaling and cytokine release in mouse macrophages, ultimately improving survival in a model of endotoxic shock