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These findings emphasize SLC7A11 in controlling cellular reactions to iron-toxicity and could offer innovative approaches for treatment (Fig

But large-scale human trials are needed to evaluate the efficacy and safety of certain peptides for specific functions before definitive claims can be made

Further studies showed that nutlin-3 increases the P53 level in wild-type U-2OS, ACHN, Caki-1 and A549 cells, which could resist ferroptosis induced by erastin-2

No change was observed in SHBG, testosterone, androstenedione, free androgen, DHEA-S, LH, or FSH in either the intervention or placebo groups [171]
